After a large number of studies and research, it has been concluded that CBD presents a new non-invasive pharmacological perspective to treat chronic pain and, moreover, it is of 100% natural origin.

Most diseases have among their symptoms a common factor, pain. Pain is a sensation that, depending on the disease or what causes it, can be very unpleasant. There are scales to try to measure to a lesser extent the pain divided between acute which is the mildest, or self-limiting, which becomes more chronic and generally disabling.

As it is already known, the cannabis plant has been used for many years as a medicinal tool. On the other hand, our organism presents an endocannabinoid system (It is a system in charge of receiving and translating all the stimuli of the cannabinoids). There are several endogenous compounds in our body that interact directly with cannabinoid receptors. Some examples of these types of compounds are anandamide and 2-AG. Among the functionalities of the cannabinoid system are physiological ones such as rest, appetite, coordination and pain.

CBD is one of the 120 compounds called phytocannabinoids that has benefits in our health and does not present any type of addiction or psychotropic effect.

Different types of pain and mechanisms

First of all, according to the Ministry of Health, pain is “an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage”.

We could say that pain travels through our nerve fibers from the periphery to the brain, which integrates and interprets the information according to various factors. This procedure is called the ascending pain pathway. From this situation, a way to extinguish pain is identified, which consists of emitting signals from the cortex to the periphery so that the sensation of pain diminishes. Several neurotransmitters participate in this process, both at the pathological and physiological levels, among which glutamate plays a major role in the nervous system and in pain control.

Glutamate is considered the excitatory neurotransmitter of the CNS and there is a large amount of research and clinical cases in which its hyperactivation is demonstrated in several pathological conditions, including chronic pain. 

Aminobutyric acid is the neurotransmitter responsible for inhibiting pain in the central nervous system, among its responsibilities is the inhibition of spinal cord neurons that are responsible for pain transmission. Pain can be classified according to whether it is acute or chronic:

Acute pain

It is the one that appears at a certain moment and is caused by something specific such as a blow, an operation. This type of pain to be caused by something specific as the injury or injury is recovering the pain will gradually decrease.


Chronic pain

On the contrary, chronic pain is that which remains for more than 6 months even if the reason for its appearance has already disappeared. The pain remains constant for several months or years and, depending on environmental or psychological factors, can trigger an increase in pain.

Examples of chronic pain can be migraines, cancer, lupus, fibromyalgia, neuropathic pain, arthritis, etc.

Acute pain has the advantage that its treatment is simple, since with anti-inflammatories or weak opiates it can be reduced, however, chronic pain such as neuropathic pain is much more difficult to reduce. The CBD is with the THC one of those components that have a therapeutic power in the treatment of various types of chronic pain.

How does CBD act on pain?

CBD is one of the most potent and pharmacologically known of the more than 100 compounds in the hemp plant, which is why there are a large number of studies that demonstrate in clinical cases how CBD is an effective remedy to treat certain types of chronic pain in reprisal of opiates. 

Cannabidiol is a component that acts on CB1 and CB2 receptors and communicates with the different types of neurotransmitters in the central nervous system. CBD has among its properties to inhibit the effects of Adenosine (linked to the transmission of pain and its chronification). Cannabidiol has a direct impact on serotonin 5HT1, which is responsible for the comorbidities associated with neuropathic pain and anxiety. That is why CBD is of great importance and its consumption is recommended for patients with chronic neuropathic pain.

Proven therapeutic uses of CBD

CBD presents a large number of studies and tests that verify that it is a crucial element in the treatment of neuropathic pain either alone or in combination with tetrahydrocannabinol and improves the sequelae that are linked to chronic pain such as depression or anxiety generated by unbearable pain. 

As we have previously discussed in other blog posts, CBD not only has benefits for chronic pain, but also has numerous benefits for epilepsy, inflammation, sleep problems, multiple sclerosis or schizophrenia.

At the moment, CBD is used to treat childhood epilepsies that had no treatment until now, but with the consumption of CBD there are improvements.

Improving quality of life in chronic pain patients with CBD

Chronic pain has consequences that are not only the persistent sensation of pain, but it is generally associated with a limitation in the quality of life of the people who suffer from it. Among the agents and reasons why pain is maintained and lasts over time are proinflammatory conditions and local vasodilatation, among others. If the situation is not redirected and the reason for the damage is not identified, the pain can trigger the onset of classic anti-inflammatory diseases such as arthritis. There are several preclinical cases that give us some support for the anti-inflammatory properties of cannabinoids (CBD stands out for being non-toxic and non-psychoactive). Chronic pain today has no treatment, we can only try to significantly reduce this effect and make patients have the least possible pain and increase their quality of life.

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